Personalis, Inc. develops, markets, and sells advanced cancer genomic tests and services in the United States and internationally. The company offers NeXT Personal, a tumor-informed liquid biopsy test for detection of minimal residual disease (MRD), therapy response and recurrence monitoring in solid tumor cancers; and ImmunoID NeXT, a tissue-based service that combines whole exome and whole transcriptome sequencing data with advanced analytics to provide a multi-dimensional view of the tumor and the tumor microenvironment from a single sample. It also provides NeXT Personal Dx, a tumor-informed liquid biopsy test for the detection of MRD; and NeXT Dx, a tumor profiling test that is used to help select therapy for a cancer patient and identify potential clinical trials for a patient. In addition, the company performs whole exome sequencing of cancer tissue and matched blood samples for diagnostic companies as an input to their products; and whole genome sequencing on human samples for research projects, such as population sequencing initiatives. Its services are used by pharmaceutical companies for translational research, biomarker discovery, the development of personalized cancer therapies, and for clinical trials, as well as tests are used by physicians to detect residual or recurrent cancer in patients, monitor cancer response to therapy, and uncover insights for therapy selection. The company's customers include pharmaceutical companies, biopharmaceutical companies, diagnostics companies, universities, non-profits, government entities, and cancer patients. The company has strategic collaboration with Tempus AI, Inc. to bring testing to colorectal cancer patients. Personalis, Inc. was incorporated in 2011 and is headquartered in Fremont, California.
5-year financial trends. Figures in USD millions.
Latest fiscal year: 2025
Year-by-year revenue, profitability, and cash flow (USD millions, last 10 years)
| Year | Revenue | EBITDA | Net Profit | FCF | ROE | Rev Growth 1Y | NP Growth 1Y |
|---|---|---|---|---|---|---|---|
| 2025 | $70M | $-71M | $-81M | $-79M | -31.1% | -17.7% | - |
| 2024 | $85M | $-70M | $-81M | $-47M | -40.0% | 15.2% | - |
| 2023 | $73M | $-97M | $-108M | $-67M | -83.7% | 13.0% | - |
| 2022 | $65M | $-105M | $-113M | $-120M | -51.9% | - | - |
Income statement, balance sheet, and cash flow as reported
Consolidated Figures in USD Millions.
| Metric | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|
| Total Revenue | 65.05 | 73.48 | 84.61 | 69.65 |
| Cost Of Revenue | 51.70 | 55.27 | 57.79 | 53.87 |
| Gross Profit | 13.35 | 18.21 | 26.82 | 15.78 |
| Operating Expense | 128.88 | 114.50 | 95.09 | 103.83 |
| Operating Income | -115.53 | -96.29 | -68.27 | -88.06 |
| EBITDA | -104.64 | -96.81 | -70.30 | -71 |
| EBIT | -113.07 | -108.10 | -81.24 | -81.04 |
| Pretax Income | -113.28 | -108.21 | -81.27 | -81.25 |
| Tax Provision | 0.04 | 0.08 | 0.02 | 0.02 |
| Net Income | -113.31 | -108.30 | -81.28 | -81.27 |
| Net Income Common Stockholders | -113.31 | -108.30 | -81.28 | -81.27 |
| Total Expenses | 180.58 | 169.78 | 152.88 | 157.71 |
| Interest Expense | 0.20 | 0.11 | 0.02 | 0.20 |
| Interest Income | 2.40 | 5.90 | 5.51 | 7.16 |
| Research And Development | 64.91 | 64.78 | 48.91 | 50.26 |
| Selling General And Administration | 63.97 | 49.73 | 46.19 | 53.57 |
| Normalized EBITDA | -104.64 | -83.17 | -70.30 | -71 |
| Normalized Income | -113.31 | -94.65 | -81.28 | -81.27 |
| Basic EPS | -2.48 | -2.25 | -1.37 | 0 |
| Diluted EPS | -2.48 | -2.25 | -1.37 | 0 |
| Tax Effect Of Unusual Items | 0 | 0 | 0 | 0 |
| Tax Rate For Calcs | 0.21 | 0 | 0.21 | 0 |
| Total Unusual Items | 0 | -13.64 | 0 | 0 |
| Total Unusual Items Excluding Goodwill | 0 | -13.64 | 0 | 0 |
| Net Income From Continuing Operation Net Minority Interest | -113.31 | -108.30 | -81.28 | -81.27 |
| Reconciled Depreciation | 8.43 | 11.30 | 10.94 | 10.05 |
| Reconciled Cost Of Revenue | 51.70 | 55.27 | 57.79 | 53.87 |
| Net Interest Income | 2.19 | 5.79 | 5.49 | 6.95 |
| Net Income From Continuing And Discontinued Operation | -113.31 | -108.30 | -81.28 | -81.27 |
| Total Operating Income As Reported | -115.53 | -109.94 | -68.27 | -88.06 |
| Diluted Average Shares | 45.70 | 48.18 | 59.25 | 0 |
| Basic Average Shares | 45.70 | 48.18 | 59.25 | 0 |
| Diluted NI Availto Com Stockholders | -113.31 | -108.30 | -81.28 | -81.27 |
| Net Income Including Noncontrolling Interests | -113.31 | -108.30 | -81.28 | -81.27 |
| Net Income Continuous Operations | -113.31 | -108.30 | -81.28 | -81.27 |
| Other Income Expense | 0.06 | -17.71 | -18.48 | -0.14 |
| Other Non Operating Income Expenses | 0.06 | -4.07 | -18.48 | -0.14 |
| Special Income Charges | 0 | -13.64 | 0 | 0 |
| Impairment Of Capital Assets | 0 | 5.57 | 0 | 0 |
| Restructuring And Mergern Acquisition | 0 | 8.08 | 0 | 0 |
| Net Non Operating Interest Income Expense | 2.19 | 5.79 | 5.49 | 6.95 |
| Interest Expense Non Operating | 0.20 | 0.11 | 0.02 | 0.20 |
| Interest Income Non Operating | 2.40 | 5.90 | 5.51 | 7.16 |
| Operating Revenue | 64.64 | 73.08 | 84.49 | 68.33 |
Healthcare sector peers, ranked by market cap
| Company | Ticker | Market Cap | P/E | P/B | ROE | EV/EBITDA |
|---|---|---|---|---|---|---|
| Personalis, Inc.this co. | PSNL | $528M | - | 1.98 | -31.1% | -4.25 |
| Rigel Pharmaceuticals, Inc. | RIGL | $540M | 1.50 | 1.37 | 93.8% | 3.43 |
| Embecta Corp. | EMBC | $536M | 5.72 | -0.84 | -14.6% | 6.16 |
| SI-BONE, Inc. | SIBN | $528M | - | 2.93 | -10.6% | -25.11 |
| Tactile Systems Technology, Inc. | TCMD | $512M | 27.44 |
| 2.31 |
| 8.7% |
| 12.18 |
| Altimmune, Inc. | ALT | $511M | - | 1.30 | -39.2% | -1.10 |
| Tectonic Therapeutic, Inc. | TECX | $510M | - | 2.02 | -29.5% | -3.09 |
| Aquestive Therapeutics, Inc. | AQST | $503M | - | -14.67 | 248.9% | -5.90 |
| XOMA Royalty Corporation | XOMA | $497M | 28.08 | 5.79 | 37.8% | 38.75 |
| Peer Median | - | 16.58 | 1.69 | -1.0% | 1.16 | |