Personalis, Inc. develops, markets, and sells advanced cancer genomic tests and services in the United States and internationally. The company offers NeXT Personal, a tumor-informed liquid biopsy test for detection of minimal residual disease (MRD), therapy response and recurrence monitoring in solid tumor cancers; and ImmunoID NeXT, a tissue-based service that combines whole exome and whole transcriptome sequencing data with advanced analytics to provide a multi-dimensional view of the tumor and the tumor microenvironment from a single sample. It also provides NeXT Personal Dx, a tumor-informed liquid biopsy test for the detection of MRD; and NeXT Dx, a tumor profiling test that is used to help select therapy for a cancer patient and identify potential clinical trials for a patient. In addition, the company performs whole exome sequencing of cancer tissue and matched blood samples for diagnostic companies as an input to their products; and whole genome sequencing on human samples for research projects, such as population sequencing initiatives. Its services are used by pharmaceutical companies for translational research, biomarker discovery, the development of personalized cancer therapies, and for clinical trials, as well as tests are used by physicians to detect residual or recurrent cancer in patients, monitor cancer response to therapy, and uncover insights for therapy selection. The company's customers include pharmaceutical companies, biopharmaceutical companies, diagnostics companies, universities, non-profits, government entities, and cancer patients. The company has strategic collaboration with Tempus AI, Inc. to bring testing to colorectal cancer patients. Personalis, Inc. was incorporated in 2011 and is headquartered in Fremont, California.
5-year financial trends. Figures in USD millions.
Latest fiscal year: 2025
Year-by-year revenue, profitability, and cash flow (USD millions, last 10 years)
| Year | Revenue | EBITDA | Net Profit | FCF | ROE | Rev Growth 1Y | NP Growth 1Y |
|---|---|---|---|---|---|---|---|
| 2025 | $70M | $-71M | $-81M | $-79M | -31.1% | -17.7% | -0.0% |
| 2024 | $85M | $-70M | $-81M | $-47M | -40.0% | 15.2% | -24.9% |
| 2023 | $73M | $-97M | $-108M | $-67M | -83.7% | 13.0% | -4.4% |
| 2022 | $65M | $-105M | $-113M | $-120M | -51.9% | - | - |
| 2021 | - | - |
Income statement, balance sheet, and cash flow as reported
Consolidated Figures in USD Millions.
| Metric | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|
| Total Revenue | - | 65.05 | 73.48 | 84.61 | 69.65 |
| Operating Revenue | - | 64.64 | 73.08 | 84.49 | 68.33 |
| Cost Of Revenue | - | 51.70 | 55.27 | 57.79 | 53.87 |
| Gross Profit | - | 13.35 | 18.21 | 26.82 | 15.78 |
| Operating Expense | - | 128.88 | 114.50 | 95.09 | 103.83 |
| Research And Development | - | 64.91 | 64.78 | 48.90 | 50.26 |
| Selling General And Administration | - | 63.97 | 49.73 | 46.19 | 53.57 |
| Total Expenses | - | 180.58 | 169.78 | 152.88 | 157.71 |
| Operating Income | - | -115.53 | -96.29 | -68.27 | -88.06 |
| Total Operating Income As Reported | - | -115.53 | -109.94 | -68.27 | -88.06 |
| EBITDA | - | -104.64 | -96.81 | -70.30 | -71 |
| Normalized EBITDA | - | -104.64 | -83.16 | -70.30 | -71 |
| EBIT | - | -113.07 | -108.10 | -81.24 | -81.04 |
| Interest Income | - | 2.40 | 5.90 | 5.51 | 7.16 |
| Interest Expense | - | 0.20 | 0.11 | 0.02 | 0.20 |
| Net Interest Income | - | 2.19 | 5.79 | 5.49 | 6.95 |
| Other Non Operating Income Expenses | - | 0.06 | -4.07 | -18.48 | -0.14 |
| Other Income Expense | - | 0.06 | -17.71 | -18.48 | -0.14 |
| Interest Income Non Operating | - | 2.40 | 5.90 | 5.51 | 7.16 |
| Interest Expense Non Operating | - | 0.20 | 0.11 | 0.02 | 0.20 |
| Net Non Operating Interest Income Expense | - | 2.19 | 5.79 | 5.49 | 6.95 |
| Pretax Income | - | -113.28 | -108.21 | -81.27 | -81.25 |
| Tax Provision | - | 0.04 | 0.08 | 0.02 | 0.02 |
| Tax Rate For Calcs | - | 0 | 0 | 0 | 0 |
| Tax Effect Of Unusual Items | - | 0 | 0 | 0 | 0 |
| Net Income Continuous Operations | - | -113.32 | -108.30 | -81.28 | -81.27 |
| Net Income From Continuing And Discontinued Operation | - | -113.32 | -108.30 | -81.28 | -81.27 |
| Net Income From Continuing Operation Net Minority Interest | - | -113.32 | -108.30 | -81.28 | -81.27 |
| Net Income | - | -113.32 | -108.30 | -81.28 | -81.27 |
| Net Income Common Stockholders | - | -113.32 | -108.30 | -81.28 | -81.27 |
| Net Income Including Noncontrolling Interests | - | -113.32 | -108.30 | -81.28 | -81.27 |
| Normalized Income | - | -113.32 | -94.65 | -81.28 | -81.27 |
| Diluted NI Availto Com Stockholders | - | -113.32 | -108.30 | -81.28 | -81.27 |
| Basic Average Shares | 43.89 | 45.70 | 48.18 | 59.25 | - |
| Diluted Average Shares | 43.89 | 45.70 | 48.18 | 59.25 | - |
| Reconciled Depreciation | - | 8.43 | 11.30 | 10.94 | 10.05 |
| Reconciled Cost Of Revenue | - | 51.70 | 55.27 | 57.79 | 53.87 |
| Total Unusual Items | 0 | 0 | -13.64 | 0 | - |
| Total Unusual Items Excluding Goodwill | 0 | 0 | -13.64 | 0 | - |
| Special Income Charges | 0 | 0 | -13.64 | 0 | - |
| Impairment Of Capital Assets | 0 | 0 | 5.56 | 0 | - |
| Restructuring And Mergern Acquisition | 0 | 0 | 8.08 | 0 | - |
Healthcare sector peers, ranked by market cap
| Company | Ticker | Market Cap | P/E | P/B | ROE | EV/EBITDA |
|---|---|---|---|---|---|---|
| Personalis, Inc.this co. | PSNL | $1.3B | -15.59 | 4.85 | -31.1% | -16.66 |
| AdaptHealth Corp. | AHCO | $1.3B | -18.70 | 0.87 | -4.7% | 6.60 |
| BioLife Solutions, Inc. | BLFS | $1.3B | -288.04 | 3.56 | -1.2% | -109.81 |
| Teladoc Health, Inc. | TDOC | $1.3B | -6.59 | 0.95 | -14.5% | 9.83 |
| Enovis Corporation | ENOV | $1.3B | -1.11 |
| - |
| - |
| - |
| - |
| - |
| 0.88 |
| -79.5% |
| -3.20 |
| Harrow, Inc. | HROW | $1.3B | -251.62 | 24.66 | -9.8% | 34.65 |
| Ardent Health, Inc. | ARDT | $1.2B | 9.08 | 0.96 | 10.5% | 5.71 |
| Alphatec Holdings, Inc. | ATEC | $1.2B | - | 98.07 | -1154.3% | - |
| Inspire Medical Systems, Inc. | INSP | $1.2B | 8.36 | 1.56 | 18.6% | 14.32 |
| Peer Median | - | -6.59 | 1.26 | -7.2% | 6.60 | |