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Equiscale · Syntellia LLC
Rhythm Pharmaceuticals, Inc., a commercial-stage biopharmaceutical company, focuses on the rare neuroendocrine diseases in the United States and internationally. The company's lead product candidate is IMCIVREE (setmelanotide), a rare melanocortin-4 receptor for the treatment of pro-opiomelanocortin (POMC), proprotein convertase subtilisin/kexin type 1, leptin receptor (LEPR) deficiency obesity, Bardet-Biedl and Alström syndrome, Prader-Willi syndrome, and hypothalamic obesity. It is in Phase 3 clinical trials for treating acquired hypothalamic obesity, congenital hypothalamic obesity, pro-opiomelanocortin (POMC) and LEPR insufficiency obesities, SRC1 deficiency obesity, and SH2B1 deficiency obesity; and in phase 2 clinical trails for the treatment of Prader-Willi syndrome and MC4R deficiency. The company is also developing bivamelagon, an investigational oral small molecule MC4R agonist that is in phase 2 clinical trial for the treatment of MC4R pathway diseases; and RM-718, a next generation MC4R peptide agonist that is in phase 1 clinical trial for the treatment of hypothalamic obesity. The company was formerly known as Rhythm Metabolic, Inc. and changed its name to Rhythm Pharmaceuticals, Inc. in October 2015. Rhythm Pharmaceuticals, Inc. was founded in 2008 and is headquartered in Boston, Massachusetts.
Rule-based from financial data. Not advice.
5-year financial trends. Figures in USD millions.
Latest fiscal year: 2025
Year-by-year revenue, profitability, and cash flow (USD millions, last 10 years)
| Year | Revenue | EBITDA | Net Profit | FCF | ROE | Rev Growth 1Y | NP Growth 1Y |
|---|---|---|---|---|---|---|---|
| 2025 | $190M | $-174M | $-197M | $-117M | -141.3% | 45.8% | -24.6% |
| 2024 | $130M | $-238M | $-261M | $-114M | -1199.3% | 68.1% | 41.1% |
| 2023 | $77M | $-168M | $-185M | $-136M | -108.8% | 227.6% | 2.0% |
| 2022 | $24M | $-174M | $-181M | $-178M | -68.5% | - | - |
Income statement, balance sheet, and cash flow as reported
Consolidated Figures in USD Millions.
| Metric | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|
| Total Revenue | - | 23.64 | 77.43 | 130.13 | 189.76 |
| Operating Revenue | - | 23.64 | 77.43 | 130.13 | 189.76 |
| Cost Of Revenue | - | 2.13 | 9.30 | 13.37 | 19.49 |
| Gross Profit | - | 21.50 | 68.13 | 116.76 | 170.26 |
| Operating Expense | - | 200.66 | 252.48 | 382.26 | 362.28 |
| Research And Development | - | 108.63 | 134.95 | 237.96 | 167.34 |
| Selling General And Administration | - | 92.03 | 117.53 | 144.30 | 194.94 |
| Total Expenses | - | 202.80 | 261.79 | 395.63 | 381.77 |
| Operating Income | - | -179.16 | -184.36 | -265.50 | -192.02 |
| Total Operating Income As Reported | - | -179.16 | -184.36 | -265.50 | -192.02 |
| EBITDA | - | -174.25 | -168.46 | -238.09 | -174.12 |
| Normalized EBITDA | - | -174.25 | -168.46 | -246.99 | -174.12 |
| EBIT | - | -175.92 | -170.22 | -239.65 | -175.46 |
| Interest Income | - | 4.03 | 13.94 | 14.71 | 15.29 |
| Interest Expense | - | 5.20 | 13.89 | 20.60 | 20.58 |
| Net Interest Income | - | -1.17 | 0.05 | -5.89 | -5.29 |
| Other Non Operating Income Expenses | - | -0.79 | 0.19 | 2.24 | 1.26 |
| Other Income Expense | - | -0.79 | 0.19 | 11.14 | 1.26 |
| Interest Income Non Operating | - | 4.03 | 13.94 | 14.71 | 15.29 |
| Interest Expense Non Operating | - | 5.20 | 13.89 | 20.60 | 20.58 |
| Net Non Operating Interest Income Expense | - | -1.17 | 0.05 | -5.89 | -5.29 |
| Pretax Income | - | -181.12 | -184.11 | -260.26 | -196.04 |
| Tax Provision | - | 0 | 0.56 | 0.35 | 0.50 |
| Tax Rate For Calcs | - | 0 | 0 | 0 | 0 |
| Tax Effect Of Unusual Items | - | 0 | 0 | 1.87 | 0 |
| Net Income Continuous Operations | - | -181.12 | -184.68 | -260.60 | -196.54 |
| Net Income From Continuing And Discontinued Operation | - | -181.12 | -184.68 | -260.60 | -196.54 |
| Net Income From Continuing Operation Net Minority Interest | - | -181.12 | -184.68 | -260.60 | -196.54 |
| Net Income | - | -181.12 | -184.68 | -260.60 | -196.54 |
| Net Income Common Stockholders | - | -181.12 | -184.68 | -264.57 | -201.92 |
| Net Income Including Noncontrolling Interests | - | -181.12 | -184.68 | -260.60 | -196.54 |
| Normalized Income | - | -181.12 | -184.68 | -267.63 | -196.54 |
| Diluted NI Availto Com Stockholders | - | -181.12 | -184.68 | -264.57 | -201.92 |
| Basic Average Shares | - | 52.12 | 57.67 | 61 | 64.98 |
| Diluted Average Shares | - | 52.12 | 57.67 | 61 | 64.98 |
| Reconciled Depreciation | - | 1.67 | 1.76 | 1.56 | 1.34 |
| Reconciled Cost Of Revenue | - | 2.13 | 9.30 | 13.37 | 19.49 |
| Total Unusual Items | - | - | - | 8.90 | - |
| Total Unusual Items Excluding Goodwill | - | - | - | 8.90 | - |
| Preferred Stock Dividends | - | - | - | 3.97 | 5.38 |
| Gain On Sale Of Security | - | - | - | 8.90 | - |
Healthcare sector peers, ranked by market cap
| Company | Ticker | Market Cap | P/E | P/B | ROE | EV/EBITDA |
|---|---|---|---|---|---|---|
| Rhythm Pharmaceuticals, Inc.this co. | RYTM | $6.0B | - | 22.25 | -74.8% | - |
| Hims & Hers Health, Inc. | HIMS | $6.5B | 50.51 | 11.99 | 23.7% | 46.06 |
| Kymera Therapeutics, Inc. | KYMR | $6.1B | - | 3.89 | -19.7% | - |
| Terns Pharmaceuticals, Inc. | TERN | $6.1B | -63.58 | 6.08 | -9.6% | -51.02 |
| PACS Group, Inc. | PACS |
| 2021 |
| - |
| - |
| - |
| - |
| - |
| - |
| - |
| $5.9B |
| 30.96 |
| 6.26 |
| 20.2% |
| 24.98 |
| Mirum Pharmaceuticals, Inc. | MIRM | $5.6B | -241.41 | 17.92 | -7.4% | 329.12 |
| Cogent Biosciences, Inc. | COGT | $5.6B | -17.03 | 10.24 | -60.1% | -17.21 |
| Liquidia Corporation | LQDA | $5.6B | -80.69 | 124.29 | -154.0% | -128.84 |
| CRISPR Therapeutics AG | CRSP | $5.5B | - | 2.86 | -30.3% | - |
| Peer Median | - | -40.31 | 8.25 | -14.6% | 3.88 | |
Historically, Jul has averaged the highest return (+40.3%); May the lowest (-13.2%).
| Year | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026 | -4.2%Negative MonthJan 2026: -4.22% | -9.5%Negative MonthFeb 2026: -9.55% | -6.2%Negative MonthMar 2026: -6.21% | -6.5%Negative MonthApr 2026: -6.45% | +8.6%Positive MonthMay 2026: +8.55% | +25.7%Positive MonthJun 2026: +25.71% | -10.6%Negative MonthJul 2026: -10.61% | +16.6%*Positive MonthAug 2026: +16.60% | — | — | — | — |
| 2025 | +6.2%Positive MonthJan 2025: +6.16% | -7.6%Negative MonthFeb 2025: -7.61% | -3.5%Negative MonthMar 2025: -3.53% | +23.1%Positive MonthApr 2025: +23.07% | -5.9%Negative MonthMay 2025: -5.92% | +3.0%Positive MonthJun 2025: +3.03% | +34.9%Positive MonthJul 2025: +34.88% | +21.0%Positive MonthAug 2025: +21.03% | -2.1%Negative MonthSep 2025: -2.09% | +12.6%Positive MonthOct 2025: +12.64% | -4.1%Negative MonthNov 2025: -4.11% | -1.9%Neutral MonthDec 2025: -1.88% |
| 2024 | -4.0%Negative MonthJan 2024: -4.05% | -1.6%Neutral MonthFeb 2024: -1.56% | -0.2%Neutral MonthMar 2024: -0.21% | -8.2%Negative MonthApr 2024: -8.24% | -10.3%Negative MonthMay 2024: -10.26% | +15.1%Positive MonthJun 2024: +15.08% | +17.4%Positive MonthJul 2024: +17.41% | -1.9%Neutral MonthAug 2024: -1.91% | +10.8%Positive MonthSep 2024: +10.78% | -8.9%Negative MonthOct 2024: -8.89% | +30.0%Positive MonthNov 2024: +29.98% | -9.8%Negative MonthDec 2024: -9.77% |
| 2023 | -6.1%Negative MonthJan 2023: -6.08% | -11.1%Negative MonthFeb 2023: -11.12% | -26.6%Negative MonthMar 2023: -26.61% | +13.1%Positive MonthApr 2023: +13.06% | -17.4%Negative MonthMay 2023: -17.40% | -1.0%Neutral MonthJun 2023: -1.02% | +8.2%Positive MonthJul 2023: +8.19% | +45.8%Positive MonthAug 2023: +45.80% | -11.9%Negative MonthSep 2023: -11.86% | +0.8%Neutral MonthOct 2023: +0.81% | +44.7%Positive MonthNov 2023: +44.66% | +37.5%Positive MonthDec 2023: +37.51% |
| 2022 | -25.8%Negative MonthJan 2022: -25.75% | +2.8%Positive MonthFeb 2022: +2.83% | +51.2%Positive MonthMar 2022: +51.18% | -45.7%Negative MonthApr 2022: -45.66% | -45.0%Negative MonthMay 2022: -45.05% | +20.6%Positive MonthJun 2022: +20.64% | +203.6%Positive MonthJul 2022: +203.61% | +79.4%Positive MonthAug 2022: +79.37% | +8.4%Positive MonthSep 2022: +8.41% | +2.7%Positive MonthOct 2022: +2.73% | +6.4%Positive MonthNov 2022: +6.36% | +8.8%Positive MonthDec 2022: +8.78% |
| 2021 | — | — | — | — | -9.0%Negative MonthMay 2021: -9.04% | -0.2%Neutral MonthJun 2021: -0.15% | -11.7%Negative MonthJul 2021: -11.70% | -24.8%Negative MonthAug 2021: -24.75% | +0.4%Neutral MonthSep 2021: +0.38% | -11.9%Negative MonthOct 2021: -11.87% | -22.2%Negative MonthNov 2021: -22.24% | +11.5%Positive MonthDec 2021: +11.51% |
| Avg±SD |
Each cell is the percentage change in closing price from the end of the prior month to the end of this month. The bottom row shows the average return for that calendar month across the selected years, plus or minus one standard deviation — the range that historically contained roughly two-thirds of outcomes. Past monthly patterns are not a forecast of future returns.
This aggregates every month by calendar position — all Januaries together, all Februaries together, and so on — to show whether a given month has leaned positive or negative historically. ‘Simple’ counts each month as +1 or −1. ‘Weighted’ gives larger moves more influence: +2 above +10%, −2 below −10%. With only 6 years of history for this asset, each month’s score reflects a small number of observations — read it as a historical tendency, not a reliable seasonal pattern.
This tracks a running tally across the asset’s full price history: each month adds or subtracts based on whether it was positive or negative. A rising line means more positive months than negative so far; a flattening or falling line means recent months have leaned negative. This measures historical month-to-month consistency, not expected future performance.
Year-to-date return is calculated by dividing each day’s closing price by the price on January 1st of that year (or the asset’s first available price if it began trading mid-year). The custom average line shows the mean YTD return at each calendar day across the selected years. The standard deviation band shows the range within which returns have historically fallen — at 1 SD, roughly two-thirds of years; at 2 SD, roughly 95%. Past year-to-date patterns do not predict future returns. The average and standard deviation band are computed from the year set chosen in “Average from”, which is independent of which year lines are displayed. The current in-progress year is excluded from these calculations, since a partial year is not comparable to complete ones. Election-cycle groupings follow the US presidential calendar and are offered only for US and crypto assets.
