Simulations Plus, Inc. develops drug discovery and development software for modeling and simulation, and prediction of molecular properties utilizing artificial intelligence and machine learning based technology worldwide. It operates through Software and Services segments. The company offers GastroPlus, which predicts absorption, biopharmaceutics, pharmacokinetics, and pharmacodynamics in humans and animals; and DDDPlus and MembranePlus simulation products. It also provides products based on mechanistic and mathematical models, such as DILIsym, NAFLDsym, ILDsym, IPFsym, RENAsym, MITOsym, OBESITYsym, and Thales products. In addition, the company offers Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) predictor for chemistry-based computer program that takes molecular structures as inputs and predicts their properties; and MedChem Designer, as well as MonolixSuite products for modeling and simulation that allows for population analyses, rapid clinical trial data analyses, and regulatory submissions. Further, it provides clinical-pharmacology-based consulting services, which includes population pharmacokinetic and pharmacodynamic modeling, exposure-response analyses, clinical trial simulations, data programming, and technical writing services in support of regulatory submissions; and early drug discovery services. Additionally, the company offers creative and insightful consulting services to support its quantitative systems pharmacology and other modeling systems. The company serves pharmaceutical, biotechnology, agrochemical, cosmetics, and food industry companies, as well as academic and regulatory agencies. Simulations Plus, Inc. was incorporated in 1996 and is headquartered in Research Triangle Park, North Carolina.
5-year financial trends. Figures in USD millions.
Latest fiscal year: 2025
Year-by-year revenue, profitability, and cash flow (USD millions, last 10 years)
| Year | Revenue | EBITDA | Net Profit | FCF | ROE | Rev Growth 1Y | NP Growth 1Y |
|---|---|---|---|---|---|---|---|
| 2025 | $79M | $15M | $-65M | $14M | -51.9% | 13.1% | -750.2% |
| 2024 | $70M | $12M | $10M | $9M | 5.5% | 17.5% | -0.1% |
| 2023 | $60M | $13M | $10M | $18M | 5.9% | 10.5% | -20.2% |
| 2022 | $54M | $18M | $12M | $14M | 7.0% | - | - |
| 2021 | - | - |
Income statement, balance sheet, and cash flow as reported
Consolidated Figures in USD Millions.
| Metric | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|
| Total Revenue | - | 53.91 | 59.58 | 70.01 | 79.18 |
| Operating Revenue | - | 53.91 | 59.58 | 70.01 | 79.18 |
| Cost Of Revenue | - | 10.82 | 11.63 | 26.86 | 32.96 |
| Gross Profit | - | 43.08 | 47.95 | 43.15 | 46.22 |
| Operating Expense | - | 28.17 | 38.72 | 37.02 | 39.73 |
| Research And Development | - | 3.21 | 4.50 | 5.75 | 6.88 |
| Selling General And Administration | - | 24.96 | 34.22 | 31.27 | 32.84 |
| Total Expenses | - | 38.99 | 50.35 | 63.88 | 72.69 |
| Operating Income | - | 14.91 | 9.22 | 6.13 | 6.49 |
| Total Operating Income As Reported | - | 14.91 | 8.72 | 6.13 | -70.73 |
| EBITDA | - | 18.48 | 13.06 | 11.80 | 14.70 |
| Normalized EBITDA | - | 19 | 14.73 | 9.89 | 91.29 |
| EBIT | - | 14.91 | 9.22 | 6.13 | 6.49 |
| Interest Income | - | 0.72 | 4.13 | 4.38 | 0.72 |
| Interest Expense | 0.02 | 0 | 0 | - | - |
| Net Interest Income | - | 0.72 | 4.13 | 4.38 | 0.72 |
| Other Income Expense | - | -0.51 | -1.66 | 1.90 | -76.59 |
| Interest Income Non Operating | - | 0.72 | 4.13 | 4.38 | 0.72 |
| Interest Expense Non Operating | 0.02 | 0 | 0 | - | - |
| Net Non Operating Interest Income Expense | - | 0.72 | 4.13 | 4.38 | 0.72 |
| Pretax Income | - | 15.12 | 11.70 | 12.41 | -69.38 |
| Tax Provision | - | 2.63 | 1.73 | 2.46 | -4.66 |
| Tax Rate For Calcs | - | 0 | 0 | 0 | 0 |
| Tax Effect Of Unusual Items | - | -0.09 | -0.25 | 0.38 | -5.13 |
| Net Income Continuous Operations | - | 12.48 | 9.96 | 9.95 | -64.72 |
| Net Income From Continuing And Discontinued Operation | - | 12.48 | 9.96 | 9.95 | -64.72 |
| Net Income From Continuing Operation Net Minority Interest | - | 12.48 | 9.96 | 9.95 | -64.72 |
| Net Income | - | 12.48 | 9.96 | 9.95 | -64.72 |
| Net Income Common Stockholders | - | 12.48 | 9.96 | 9.95 | -64.72 |
| Net Income Including Noncontrolling Interests | - | 12.48 | 9.96 | 9.95 | -64.72 |
| Normalized Income | - | 12.91 | 11.38 | 8.43 | 6.74 |
| Diluted NI Availto Com Stockholders | - | 12.48 | 9.96 | 9.95 | -64.72 |
| Basic Average Shares | - | 20.20 | 20.08 | 19.99 | 20.10 |
| Diluted Average Shares | - | 20.75 | 20.46 | 20.30 | 20.10 |
| Reconciled Depreciation | - | 3.57 | 3.84 | 5.66 | 8.21 |
| Reconciled Cost Of Revenue | - | 10.82 | 11.63 | 26.86 | 32.96 |
| Total Unusual Items | - | -0.51 | -1.66 | 1.90 | -76.59 |
| Total Unusual Items Excluding Goodwill | - | -0.51 | -1.66 | 1.90 | -76.59 |
| Special Income Charges | - | -0.28 | -1.19 | 1.64 | -76.60 |
| Write Off | - | - | 0.50 | 0 | 77.22 |
| Restructuring And Mergern Acquisition | - | 0.28 | 0.68 | -1.64 | -0.64 |
| Gain On Sale Of Security | - | -0.23 | -0.48 | 0.27 | 0.01 |
| General And Administrative Expense | - | 20.09 | 27.66 | 22.35 | 20.94 |
| Other Gand A | - | 20.09 | 27.66 | 22.35 | 20.94 |
| Gain On Sale Of Ppe | - | 0 | -0.01 | 0 | -0.02 |
| Selling And Marketing Expense | - | 4.88 | 6.56 | 8.91 | 11.90 |
Healthcare sector peers, ranked by market cap
| Company | Ticker | Market Cap | P/E | P/B | ROE | EV/EBITDA |
|---|---|---|---|---|---|---|
| Simulations Plus, Inc.this co. | SLP | $336M | -5.20 | 2.70 | -51.9% | 20.82 |
| Atea Pharmaceuticals, Inc. | AVIR | $354M | -2.23 | 1.28 | -57.5% | -1.43 |
| Greenwich LifeSciences, Inc. | GLSI | $347M | -21.99 | 136.99 | -623.1% | - |
| Larimar Therapeutics, Inc. | LRMR | $342M | - | 4.38 | -212.2% | - |
| Enanta Pharmaceuticals, Inc. | ENTA | $341M |
| - |
| - |
| - |
| - |
| - |
| -4.17 |
| 5.27 |
| -126.5% |
| -5.14 |
| Verastem, Inc. | VSTM | $339M | -1.62 | 5.93 | -366.2% | -1.07 |
| 908 Devices Inc. | MASS | $334M | 17.11 | 2.32 | 13.6% | -12.61 |
| Abeona Therapeutics Inc. | ABEO | $332M | 4.66 | 2.08 | 44.7% | 3.54 |
| Humacyte, Inc. | HUMA | $331M | -8.10 | 106.40 | -1313.4% | -15.52 |
| Peer Median | - | -2.23 | 4.82 | -169.4% | -3.29 | |