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Equiscale · Syntellia LLC
4D Molecular Therapeutics, Inc., a late-stage biotechnology company, engages in the development of adeno-associated virus vectors from its proprietary synthetic vector discovery platform, Therapeutic Vector Evolution in the Netherlands and the United States. The company's lead product candidate is 4D-150 for the treatment of retinal vascular diseases by providing multi-year sustained production of anti-VEGF from the retina with intravitreal injection, as well as for treating wet age-related macular degeneration and diabetic macular edema. It is also developing 4D-710, which is in early-stage study for the treatment of cystic fibrosis; 4D-175 that is in preclinical stage for treating geographic atrophy; and 4D-725, which is in preclinical stage for the treatment of alpha-1 anti-trypsin deficiency lung disease. 4D Molecular Therapeutics, Inc. has collaboration and licensing agreements with Otsuka Pharmaceutical Co., Ltd. The company was founded in 2013 and is headquartered in EmeryVille, California.
Rule-based from financial data. Not advice.
5-year financial trends. Figures in USD millions.
Latest fiscal year: 2025
Year-by-year revenue, profitability, and cash flow (USD millions, last 10 years)
| Year | Revenue | EBITDA | Net Profit | FCF | ROE | Rev Growth 1Y | NP Growth 1Y |
|---|---|---|---|---|---|---|---|
| 2025 | $85M | $-152M | $-140M | $-110M | -27.7% | 230194.6% | -12.9% |
| 2024 | $0M | $-181M | $-161M | $-138M | -31.5% | -99.8% | 59.5% |
| 2023 | $21M | $-107M | $-101M | $-79M | -32.8% | 562.3% | -6.2% |
| 2022 | $3M | $-106M | $-107M | $-98M | -46.5% | - | - |
Income statement, balance sheet, and cash flow as reported
Consolidated Figures in USD Millions.
| Metric | 2021 | 2022 | 2023 | 2024 | 2025 |
|---|---|---|---|---|---|
| Total Revenue | - | 3.13 | 20.72 | 0.04 | 85.21 |
| Operating Revenue | - | 3.13 | 20.72 | 0.04 | 85.21 |
| Operating Expense | - | 113.16 | 133.59 | 187.88 | 244.76 |
| Research And Development | - | 80.25 | 97.10 | 141.30 | 195.70 |
| Selling General And Administration | - | 32.91 | 36.49 | 46.58 | 49.06 |
| Total Expenses | - | 113.16 | 133.59 | 187.88 | 244.76 |
| Operating Income | - | -110.03 | -112.87 | -187.84 | -159.55 |
| Total Operating Income As Reported | - | -110.03 | -112.87 | -187.84 | -159.55 |
| EBITDA | - | -106.15 | -107.12 | -181.14 | -151.92 |
| Normalized EBITDA | - | -106.15 | -107.12 | -181.14 | -151.92 |
| EBIT | - | -110.03 | -112.87 | -187.84 | -159.55 |
| Interest Income | - | 2.57 | 12.21 | 27.05 | 19.48 |
| Net Interest Income | - | 2.57 | 12.21 | 27.05 | 19.48 |
| Other Non Operating Income Expenses | - | -0.04 | -0.18 | -0.08 | -0.04 |
| Other Income Expense | - | -0.04 | -0.18 | -0.08 | -0.04 |
| Interest Income Non Operating | - | 2.57 | 12.21 | 27.05 | 19.48 |
| Net Non Operating Interest Income Expense | - | 2.57 | 12.21 | 27.05 | 19.48 |
| Pretax Income | - | -107.49 | -100.84 | -160.87 | -140.11 |
| Tax Rate For Calcs | - | 0 | 0 | 0 | 0 |
| Tax Effect Of Unusual Items | - | 0 | 0 | 0 | 0 |
| Net Income Continuous Operations | - | -107.49 | -100.84 | -160.87 | -140.11 |
| Net Income From Continuing And Discontinued Operation | - | -107.49 | -100.84 | -160.87 | -140.11 |
| Net Income From Continuing Operation Net Minority Interest | - | -107.49 | -100.84 | -160.87 | -140.11 |
| Net Income | - | -107.49 | -100.84 | -160.87 | -140.11 |
| Net Income Common Stockholders | - | -107.49 | -100.84 | -160.87 | -140.11 |
| Net Income Including Noncontrolling Interests | - | -107.49 | -100.84 | -160.87 | -140.11 |
| Normalized Income | - | -107.49 | -100.84 | -160.87 | -140.11 |
| Diluted NI Availto Com Stockholders | - | -107.49 | -100.84 | -160.87 | -140.11 |
| Basic Average Shares | 27.73 | 32.35 | 39.13 | 53.94 | - |
| Diluted Average Shares | 27.73 | 32.35 | 39.13 | 53.94 | - |
| Reconciled Depreciation | - | 3.88 | 5.75 | 6.70 | 7.62 |
| General And Administrative Expense | - | 32.91 | 36.49 | 46.58 | 49.06 |
| Other Gand A | - | 32.91 | 36.49 | 46.58 | 49.06 |
Healthcare sector peers, ranked by market cap
| Company | Ticker | Market Cap | P/E | P/B | ROE | EV/EBITDA |
|---|---|---|---|---|---|---|
| 4D Molecular Therapeutics, Inc.this co. | FDMT | $523M | -3.73 | 1.03 | -27.7% | -3.19 |
| Tectonic Therapeutic, Inc. | TECX | $550M | -7.41 | 2.19 | -29.5% | -4.16 |
| Strata Critical Medical, Inc. | SRTA | $542M | 13.10 | 1.94 | 14.8% | -36.28 |
| XOMA Royalty Corporation | XOMA | $532M | 16.77 | 6.34 | 37.8% | 12.14 |
| Aquestive Therapeutics, Inc. |
| 2021 |
| - |
| - |
| - |
| - |
| - |
| - |
| - |
| AQST |
| $519M |
| -6.20 |
| -15.43 |
| 248.9% |
| -6.66 |
| Pacific Biosciences of California, Inc. | PACB | $506M | -0.93 | 94.65 | -10214.5% | -7.50 |
| Arvinas, Inc. | ARVN | $499M | -6.18 | 1.15 | -18.6% | -3.23 |
| AngioDynamics, Inc. | ANGO | $497M | -14.62 | 2.72 | -18.6% | 256.27 |
| Standard BioTools Inc. | LAB | $496M | -6.62 | 1.17 | -17.7% | -4.73 |
| Peer Median | - | -6.19 | 2.06 | -18.1% | -4.45 | |
Historically, Nov has averaged the highest return (+38.5%); Apr the lowest (-8.3%).
| Year | Jan | Feb | Mar | Apr | May | Jun | Jul | Aug | Sep | Oct | Nov | Dec |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2026 | +18.1%Positive MonthJan 2026: +18.13% | +9.0%Positive MonthFeb 2026: +9.03% | -3.6%Negative MonthMar 2026: -3.62% | -4.7%Negative MonthApr 2026: -4.73% | +11.7%Positive MonthMay 2026: +11.72% | +34.2%Positive MonthJun 2026: +34.21% | -23.5%Negative MonthJul 2026: -23.46% | +64.6%*Positive MonthAug 2026: +64.64% | — | — | — | — |
| 2025 | +0.5%Neutral MonthJan 2025: +0.54% | -19.1%Negative MonthFeb 2025: -19.11% | -28.7%Negative MonthMar 2025: -28.70% | +4.3%Positive MonthApr 2025: +4.33% | +7.4%Positive MonthMay 2025: +7.42% | +2.5%Positive MonthJun 2025: +2.49% | +21.3%Positive MonthJul 2025: +21.29% | +36.9%Positive MonthAug 2025: +36.89% | +41.1%Positive MonthSep 2025: +41.07% | +32.3%Positive MonthOct 2025: +32.34% | +1.4%Neutral MonthNov 2025: +1.39% | -35.7%Negative MonthDec 2025: -35.68% |
| 2024 | -14.9%Negative MonthJan 2024: -14.86% | +62.4%Positive MonthFeb 2024: +62.43% | +13.7%Positive MonthMar 2024: +13.70% | -24.9%Negative MonthApr 2024: -24.89% | +0.2%Neutral MonthMay 2024: +0.17% | -12.4%Negative MonthJun 2024: -12.43% | -15.5%Negative MonthJul 2024: -15.53% | -15.3%Negative MonthAug 2024: -15.34% | -28.0%Negative MonthSep 2024: -27.98% | -25.9%Negative MonthOct 2024: -25.90% | -2.1%Negative MonthNov 2024: -2.12% | -29.0%Negative MonthDec 2024: -28.95% |
| 2023 | -5.2%Negative MonthJan 2023: -5.22% | -8.6%Negative MonthFeb 2023: -8.60% | -10.7%Negative MonthMar 2023: -10.65% | +4.8%Positive MonthApr 2023: +4.77% | +1.9%Neutral MonthMay 2023: +1.94% | -1.6%Neutral MonthJun 2023: -1.58% | +1.3%Neutral MonthJul 2023: +1.27% | -11.0%Negative MonthAug 2023: -11.04% | -21.8%Negative MonthSep 2023: -21.81% | -15.6%Negative MonthOct 2023: -15.63% | +18.4%Positive MonthNov 2023: +18.44% | +59.3%Positive MonthDec 2023: +59.28% |
| 2022 | -28.0%Negative MonthJan 2022: -27.99% | -13.3%Negative MonthFeb 2022: -13.29% | +10.4%Positive MonthMar 2022: +10.36% | -21.2%Negative MonthApr 2022: -21.23% | -36.3%Negative MonthMay 2022: -36.27% | -8.0%Negative MonthJun 2022: -8.04% | +34.7%Positive MonthJul 2022: +34.67% | -16.4%Negative MonthAug 2022: -16.38% | +2.3%Positive MonthSep 2022: +2.29% | +7.7%Positive MonthOct 2022: +7.71% | +179.1%Positive MonthNov 2022: +179.10% | -8.1%Negative MonthDec 2022: -8.11% |
| 2021 | — | — | — | — | -31.4%Negative MonthMay 2021: -31.37% | -9.3%Negative MonthJun 2021: -9.34% | +3.3%Positive MonthJul 2021: +3.28% | +22.8%Positive MonthAug 2021: +22.84% | -11.7%Negative MonthSep 2021: -11.72% | -10.9%Negative MonthOct 2021: -10.90% | -4.3%Negative MonthNov 2021: -4.29% | -4.6%Negative MonthDec 2021: -4.61% |
| Avg±SD |
Each cell is the percentage change in closing price from the end of the prior month to the end of this month. The bottom row shows the average return for that calendar month across the selected years, plus or minus one standard deviation — the range that historically contained roughly two-thirds of outcomes. Past monthly patterns are not a forecast of future returns.
This aggregates every month by calendar position — all Januaries together, all Februaries together, and so on — to show whether a given month has leaned positive or negative historically. ‘Simple’ counts each month as +1 or −1. ‘Weighted’ gives larger moves more influence: +2 above +10%, −2 below −10%. With only 6 years of history for this asset, each month’s score reflects a small number of observations — read it as a historical tendency, not a reliable seasonal pattern.
This tracks a running tally across the asset’s full price history: each month adds or subtracts based on whether it was positive or negative. A rising line means more positive months than negative so far; a flattening or falling line means recent months have leaned negative. This measures historical month-to-month consistency, not expected future performance.
Year-to-date return is calculated by dividing each day’s closing price by the price on January 1st of that year (or the asset’s first available price if it began trading mid-year). The custom average line shows the mean YTD return at each calendar day across the selected years. The standard deviation band shows the range within which returns have historically fallen — at 1 SD, roughly two-thirds of years; at 2 SD, roughly 95%. Past year-to-date patterns do not predict future returns. The average and standard deviation band are computed from the year set chosen in “Average from”, which is independent of which year lines are displayed. The current in-progress year is excluded from these calculations, since a partial year is not comparable to complete ones. Election-cycle groupings follow the US presidential calendar and are offered only for US and crypto assets.
